Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer.
By A. Fu, Bingqing Yao, Tingting Dong, Yongyi Chen, Jianguo Yao, Yu Liu, Hang Li, Huiru Bai, Xiaoqin Liu, Yue Zhang and 4 more. Cell, 2022
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Tumor-resident intracellular microbiota is an emerging tumor component that has been documented for a variety of cancer types with unclear biological functions. Here, we explored the functional significance of these intratumor bacteria, primarily using a murine spontaneous breast-tumor model MMTV-PyMT. We found that depletion of intratumor bacteria significantly reduced lung metastasis without affecting primary tumor growth. During metastatic colonization, intratumor bacteria carried by circulating tumor cells promoted host-cell survival by enhancing resistance to fluid shear stress by reorganizing actin cytoskeleton. We further showed that intratumor administration of selected bacteria strains isolated from tumor-resident microbiota promoted metastasis in two murine tumor models with significantly different levels of metastasis potential. Our findings suggest that tumor-resident microbiota, albeit at low biomass, play an important role in promoting cancer metastasis, intervention of which might therefore be worth exploring for advancing oncology care.
Subfields: Biotechnology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/3922339358b525a2518783cf5eccf62b80c389f2
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Citations in the corpus
- Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment (2023, positive): “Viable Lr within the tumor is necessary and sufficient to mediate antitumor effects Accumulating evidence suggests the presence of a tumor micro-biome in gut-distal cancers, 24–27 and live bacteria have been recovered from breast 26,28 and pancreatic patient tumors.”