The maturation of aperiodic EEG activity across development reveals a progressive differentiation of wakefulness from sleep

By J. Favaro, M. Colombo, E. Mikulan, S. Sartori, M. Nosadini, M. Pelizza, Mario Rosanova, Simone Sarasso, Marcello Massimini, I. Toldo. 2023

Subfields: Cognitive Neuroscience, Developmental Neuroscience

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In Cognitive Neuroscience

Citations in the corpus

The development of aperiodic neural activity in the human brain (2024, unknown): “Scalp-EEG studies have consistently demonstrated an age-related flattening of the aperiodic slope, often with a frontal-central distribution 4,6,27,58,72–74 .”
Characterization of aperiodic and theta activity in preterm infants using EEG: Insights into cerebral maturation and inter-individual variability (2026, unknown): “It occurs during a period (the last trimester of pregnancy) when brain development follows a highly orchestrated sequence of neurobiological processes, including neuronal migration, synaptogenesis, growth of connections and establishment of cerebral networks (Kostovi ´ c and Juda ˇ s, 2015).”
Revolutionizing Pediatric Neurophysiology With Magnetoencephalography (2026, unknown): “…from an average of EEG channels (Karalunas et al. 2022; Tröndle et al. 2022) or via two or more regional clusters of EEG sensors (Tröndle et al. 2022; Cellier et al. 2021; Carter Leno et al. 2021; Rico-Picó et al. 2023; Favaro et al. 2023; Hill, Clark, et al. 2022; Schaworonkow and Voytek 2021).”
The Interaction between Sleep and Development on Wake EEG Oscillations (2026, unknown): “Notably, the change in aperiodic exponents with age and sleep depth affects primarily lower frequencies (Favaro et al., 2023), whereas the overnight wake EEG changes affect primarily higher frequencies (Fig.”
Resting-state periodic and aperiodic brain oscillations from birth to preschool years: Aperiodic maturity predicts developmental course (2026, unknown): “…on command, and as a result almost all infant/toddler RS studies acquire data while the child is at rest with eyes open, often while viewing visual stimuli (Stroganova et al., 1999; Carter Leno, 2021; Schaworonkow and Voytek, 2021; Karalunas, 2022; Favaro, 2023; Vandewouw, 2024; Wilkinson, 2024).”
Confirmation of a Useful Dark‐Room Resting‐State Procedure: Periodic and Aperiodic MEG Activity in Children (2026, unknown): “…RS measures are typically obtained while the infant/toddler is at rest with the eyes open, sometimes viewing visual stimuli (Carter Leno et al. 2021; Schaworonkow and Voytek 2021; Karalunas et al. 2022; Favaro et al. 2023; Vandewouw et al. 2024; Wilkinson et al. 2024; Stroganova et al. 1999).”
Age and gender-related neurophysiological changes in sleep and wake states during childhood (2026, unknown): “While Favaro et al. (Favaro et al., 2023) previously reported a decrease in the aperiodic slope from 2 to 17 years old during wakefulness (but not during sleep), we found that be-tween the ages of 5 and 12, changes in the slopes were observed only in girls, not in boys.”
Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans (2025, unknown): “In this study, we leveraged this model by directly comparing EEG recordings from awake hemispherotomy patients with wakefulness and NREM sleep recordings in a pediatric reference dataset, with an age compatible to that of the patients [68].”
The development of aperiodic and periodic resting-state power between early childhood and adulthood: New insights from optically pumped magnetometers (2024, methodology): “…maturational changes in E/I balance, specifically a shift towards excitation with increased age, consistent with the existing developmental EEG work (Cellier et al., 2021; Favaro et al., 2023; A. T. Hill et al., 2022a; McSweeney et al., 2021, 2023; Schaworonkow and Voytek, 2021; Tr ¨ ondle et…”
Aperiodic and Hurst EEG exponents across early human brain development: A systematic review (2024, unknown): “Drug action on AE magnitude also appears to vary based on sleep state (Salvatore et al., 2024), Drug action on AE magnitude also appears to vary based on sleep state (Sal-vatore et al., 2024), for both induced (Leroy et al., 2023) or natural sleep (Favaro et al., 2023).”