SAK/PLK4 is required for centriole duplication and flagella development.

By Mónica Bettencourt-Dias, A. Rodrigues-Martins, L. Carpenter, M. Riparbelli, Laurent Lehmann, M. Gatt, N. Carmo, François Balloux, G. Callaini, David Glover. Current Biology, 2005

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Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy (2010, background): “Both gain-of-function and loss-of-function approaches clearly showed that the presence of PLK4 is crucial for the duplication of the centriole”
Flies without centrioles. (2006, background): “The polo-like kinase Plk-4/Sak is essential for centriole replication (Bettencourt-Dias et al., 2005; Habedanck et al., 2005), and Drosophila sak hypomorphic mutant third-instar larval brains appear to lack centrioles in 20% of their cells, yet they develop into adults at rates that are only slightl”
Centrioles, centrosomes, and cilia in health and disease. (2009, background): “Furthermore, Polo-like kinase 4 (Plk4; also known as Sak), a distant member of the Polo kinase family, was found to be a key regulator of centriole biogenesis in both the centriolar (Bettencourt-Dias et al., 2005; Habedanck et al., 2005) and acentriolar pathways (Peel et al.”
Plk4-induced centriole biogenesis in human cells. (2007, background): “Homologs of nematode Sas-4 and Sas-6 were also required for centriole biogenesis in Drosophila (Peel et al., 2007; Rodrigues-Martins et al., 2007) and a requirement for Sas-6 was demonstrated for human cells (Leidel et al., 2005), suggesting that fundamental aspects of centriole biogenesis have most”