Streptozotocin‐Induced Diabetic Models in Mice and Rats

By B. Furman. Current Protocols in Pharmacology, 2015

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Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this unit are protocols for producing STZ‐induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition. © 2015 by John Wiley & Sons, Inc.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Surgery

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