Theta oscillations synchronize human medial prefrontal cortex and amygdala during fear learning

By Si Chen, Zheng Tan, Wenran Xia, C. A. Gomes, Xilei Zhang, Wenjing Zhou, Shuli Liang, Nikolai Axmacher, Liang Wang. 2021

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Theta oscillations between the ventromedial prefrontal cortex and amygdala support dynamic representations of threat and safety (2025, unknown): “…anterior cingulate, dACC or dorsal mPFC, dmPFC as human homolog) mediates fear acquisition and expression, and IL (i.e., ventral mPFC, vmPFC as human homolog) mediates fear extinction (Burgos-Robles et al., 2009; Chen et al., 2021; Hennings et al., 2022; Marek et al., 2019; Milad & Quirk, 2012).”
Intracranial EEG signals disentangle multi-areal neural dynamics of vicarious pain perception (2024, methodology): “Note that channels from both hemispheres were collapsed to improve statistical power 31,32,35 .”
An intracranial dissection of human escape circuits (2024, unknown): “Previous rodent studies have highlighted the importance of PFC in top-down control of threat reactivity 47,75 . iEBS has been used to validate causal relationships between a speci ﬁ c brain region and its corresponding cognitive function 76,77 .”
Developmental differences in threat learning are associated with changes in frontal-central theta activity (2025, unknown): “Studies in both rodents and humans suggest theta frequency oscillations (4–7 Hz) may correspond to connectivity between amygdala and anterior midcingulate cortex (AMC) and among other fear-related nodes [22, 28, 29] and may play a central role in fear expression [30].”