Intrinsic disorder in transcription factors.

By Jiangang Liu, Jiangang Liu, N. Perumal, Christopher J. Oldfield, E. Su, Vladimir N Uversky, A. Keith Dunker. Biochemistry, 2006

727 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/385e9534c0f8cadb3d9a9fb5a46f76897eb124db

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Citations in the corpus

Natively unstructured regions in proteins identified from contact predictions (2007, background): “Protein regions involved in alternative splicing and transcription are also often unstructured (Liu, et al., 2006; Romero, et al., 2006).”
Prediction of Protein Binding Regions in Disordered Proteins (2009, methodology): “This means that p1 and p2 were randomly selected from the interval [21;1] and p3 was selected from the interval [0;1] in a way that the sum of their squares is always equal to 1.”
Natively Unstructured Loops Differ from Other Loops (2007, background): “, alternative splicing [63] and transcription [64]) and in cancerassociated signaling proteins [65].”
Prediction of intrinsic disorder and its use in functional proteomics. (2007, background): “ID was shown to be highly abundant in signaling proteins (43), transcription factors (92), proteins with PEST regions (e.”
Intrinsic Disorder Is a Common Feature of Hub Proteins from Four Eukaryotic Interactomes (2006, background): “DNA-binding domains are frequently well-ordered [32], whereas RNA-binding proteins can be completely disordered (such as ribosomal proteins when separated from the ribosome) [15], or they can carry long disordered domains (such as SR splicing factors) [33].”
Disorder Prediction Methods, Their Applicability to Different Protein Targets and Their Usefulness for Guiding Experimental Studies (2015, background): “Proteins containing disorder are now understood to be involved in various regulatory roles; intrinsic disorder is believed to allow for binding to multiple targets and also to increase efficiency of binding [13,14].”
Intrinsic disorder and functional proteomics. (2007, methodology): “The overwhelming prevalence of ID in TFs was been recently established using a set of ID predictors (195).”
Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners (2008, result): “Both predictors give good agreement with the experimental determination of intrinsic disorder [83,91-109], and in the case of p53 both of their predictions agree well with experimental characterization.”
Transcription factors activate genes through the phase separation capacity of their activation domains (2018, result): “An analysis of mammalian TFs confirmed that TFs and their putative ADs are enriched in IDRs, as previous analyses have shown (Liu et al., 2006; Staby et al., 2017) (Figure 5A).”
Comprehensive review of methods for prediction of intrinsic disorder and its molecular functions (2017, background): “2 disordered proteins and regions are crucial for numerous cellular functions including regulation of transcription, translation [7-10] and cell signaling [11-15].”