Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.

By S. Friedman. Physiological Reviews, 2008

2,794 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Hepatology

View Paper: https://www.semanticscholar.org/paper/38562ab30409eb5438ba08427016d3dc8e15700c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. M. Pinzani
2. Y. Saiman
3. J. Puche
4. S. Friedman
5. Robert F. Schwabe
6. M. Parola
7. E. Seki
8. TA Wynn

In Genetics

1. Y. Saiman
2. J. Puche
3. Robert F. Schwabe
4. Natascha Roehlen
5. E. Crouchet
6. T. Baumert
7. M. Pinzani
8. M. Parola

In Hepatology

1. Y. Saiman
2. J. Puche
3. M. Parola
4. Robert F. Schwabe
5. TA Wynn
6. E. Seki
7. M. Pinzani
8. T. Donohue

Citations in the corpus

• Targeting TGF-β signal transduction for fibrosis and cancer therapy (2022, background): “In addition, they give rise to myofibroblasts (MFBs), which represent the primary producer of collagen and other ECM proteins [71, 72].”
• Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives (2020, background): “The initiation stage is triggered by paracrine stimulation of HSCs through the products of injured hepatocytes, signals from the resident Kupffer cells and endothelial cells, as well as Reactive Oxygen Species (ROS) and lipid peroxides exposure [58].”
• Macrophages: Master Regulators of Inflammation and Fibrosis (2010, background): “EVIDENCE MACROPHAGES CONTROL FIBROSIS PROGRESSION AND RESOLUTION Macrophages are almost always found in close proximity with collagen-producing myofibroblasts, and there is strong evidence that this interaction is reciprocal.(4) Activated HSCs attract and stimulate macrophages with multiple chemokin”
• Hepatic Inflammation and Fibrosis: Functional Links and Key Pathways (2015, background): “Putting these findings into context, it is likely that HSCs exert specific function in the regulation of inflammation within the fibrotic liver: (1) After their initial activation, HSCs require “perpetuation” signals that maintain HSC in their activated state and contribute to their survival.(16) It”
• Hepatic stellate cells in liver development, regeneration, and cancer. (2013, background): “Activated hepatic stellate cells produce a wide array of cytokines and chemokines (2).”
• Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues. (2019, background): “Experimental and clinical data indicate that activated/transdifferentiated HSC represent the major source of hepatic MFs, whatever the etiology (Friedman, 2008; Tsuchida and Friedman, 2017).”
• Mammalian Krüppel-Like Factors in Health and Diseases (2010, background): “Hepatic stellate cells (HSCs) are the major source of extracellular matrix during liver fibrosis; they are often activated upon liver injury and during subsequent wound healing (142).”