Age-dependent dysregulation of innate immunity

By A. Shaw, D. Goldstein, Ruth R. Montgomery. Nature reviews. Immunology, 2013

980 citations recorded by the source corpus.

As we age, the innate immune system becomes dysregulated and is characterized by persistent inflammatory responses that involve multiple immune and non-immune cell types and that vary depending on the cell activation state and tissue context. This ageing-associated basal inflammation, particularly in humans, is thought to be induced by several factors, including the reactivation of latent viral infections and the release of endogenous damage-associated ligands of pattern recognition receptors (PRRs). Innate immune cell functions that are required to respond to pathogens or vaccines, such as cell migration and PRR signalling, are also impaired in aged individuals. This immune dysregulation may affect conditions associated with chronic inflammation, such as atherosclerosis and Alzheimer's disease.

Subfields: Immunology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/38184597d190629524e6f31f3633392ed0961823

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In Immunology

1. A. Aschenbrenner
2. M. Mack
3. Joachim L. Schultze
4. Antero Salminen
5. K. Kaarniranta

In Molecular Biology

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In Neurology

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Citations in the corpus

• JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age (2015, neutral): “system (53) or altered redox homeostasis (54).”
• Immune Response, Inflammation, and the Clinical Spectrum of COVID-19 (2020, background): “Immunosenescence present in the elderly affects innate immunity (116), but mainly T cell-dependent adaptive responses (117–120).”
• Dysregulation of immune response in patients with COVID-19 in Wuhan, China (2020, background): “14 immune response is the first line of defense against viral infections, however, when immune response is dysregulated, it will result in an excessive inflammation, even cause death[18].”
• Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions (2020, neutral): “Accordingly increased age is associated with a poorer outcome [3,6,23,51].”
• The senescence-associated secretory phenotype and its physiological and pathological implications (2024, neutral): “Ageing is associated with impairment in the immune system, which is characterized by the dysregulation of immune cell function and hyper-activity of pro-inflammatory pathways in both the innate and adaptive immune compartments 182,183 .”
• Inflammation and its role in age-related macular degeneration (2016, background): “Those include changes in the PRR expression, aberrant signaling and disturbed cytokine production, as well as decreased migration, phagocytosis, and killing of ingested micro-organisms [201].”
• Sex-based differences in susceptibility to SARS-CoV infection (2017, background): “Of note, differences were less apparent in individuals aged $75 y, possibly because of the enhanced mortality in all elderly, regardless of sex, due to dysregulated immune responses (38).”
• COVID-19 and the human innate immune system (2021, background): “In this setting, with defective functionality in the myeloid compartment along an increase in proinflammatory monocytes and higher baseline levels of many proinflammatory mediators such as IL6 (Shaw et al., 2013), it can be hypothesized that the initiated innate immune response during COVID-19 exace”
• Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China (2020, background): “A rapid and well-coordinated innate immune response is the first line of defense against viral infections; however, when the immune response is dysregulated, it will result in excessive inflammation, and even cause death [17].”