Precision and functional specificity in mRNA decay

By Yulei Wang, C. Liu, John D. Storey, Robert Tibshirani, Daniel Herschlag, Patrick O. Brown. Proceedings of the National Academy of Sciences of the United States of America, 2002

776 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/367ece97387fef300383f32e4f53be4ce4c426f6

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Citations in the corpus

Single-RNA counting reveals alternative modes of gene expression in yeast (2008, background): “In yeast, however, such buffering is not possible, as the average protein half-life is short and only twice as long as the average mRNA half-lif”
RNA regulons: coordination of post-transcriptional events (2007, methodology): “Comparing gene-expression profiles following the blockage of transcription using RNA polymerase mutants revealed that mRNAs from the same stability group were functionally related, encoding components of previously known regulatory pathways including glycolysis, pheromone signal transduction and tra”
Global analysis of protein localization in budding yeast (2003, background): “Recent studies have taken a genome-wide approach to analysing messenger RNA abundance and stabilit”
Noise Minimization in Eukaryotic Gene Expression (2004, methodology): “Transcription rates were calculated from mRNA abundances and decay rates in log-phase yeast growing in rich glucose medium (Wang et al. 2002) according to the steady-state equation R = ln(0.”
Codon optimality is a major determinant of mRNA stability (2015, background): “These transcripts were determined to be stable both previously and in our genome-wide analysis (median half-life = 43.4 min; Wang et al., 2002).”
Global analysis of protein expression in yeast (2003, methodology): “The average protein per mRNA ratio is 4,800 using this measure of mRNA levels, and is 4,200 using an alternative mRNA abundance measurement based on a microarray analysis comparing mRNA to genomic DNA level”
Extensive Association of Functionally and Cytotopically Related mRNAs with Puf Family RNA-Binding Proteins in Yeast (2004, methodology): “In support of this idea, it has recently been suggested that mRNA decay in the cytoplasm of S. cerevisiae occurs in distinct loci (Sheth and Parker 2003) and, further, that mRNAs encoding different subunits of stoichiometric complexes do indeed have concordant decay rates (Wang et al. 2002b).”
Diverse RNA-Binding Proteins Interact with Functionally Related Sets of RNAs, Suggesting an Extensive Regulatory System (2008, neutral): “abundance [19], half-life [19], 39-UTR length [63], 59-UTR”
MicroRNAs in development and disease. (2011, background): “Furthermore, posttranscriptional coregulation of functionally related genes is well supported by two observations: 1) the positive correlation between mRNA and protein abundance of functionally related genes, but not those of whole cell or separate cellular compartments (40); and 2) mRNA of function”
Evolutionary and Physiological Importance of Hub Proteins (2006, neutral): “Evolutionary rate data (non-synonymous substitution per site and synonymous substitution per site) for the four-way stricto sensu species alignments for 3,036 genes [39], proteome-wide protein abundance [40], and genome-wide yeast mRNA half-life [41] datasets were as described.”