The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein.

By N. Van Damme, D. Goff, Chris Katsura, R. Jorgenson, R. Mitchell, Marc C. Johnson, E. Stephens, J. Guatelli. Cell Host and Microbe, 2008

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Origins of HIV and the AIDS pandemic. (2011, background): “Viruses from these two lineages are quite divergent, differing at about 30%–50% of sites in their Gag, Pol, and Env protein sequences (Vanden Haesevelde et al. 1996).”
Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol (2012, background): “…a 3–5’ exonuclease, degrades single stranded viral RNA; PKR inhibits viral translation through suppression of eIF2a elongation factors and tetherin prevents release of virions from the cell (Degols et al., June; García et al., 2006; Neil et al., 2008; Van Damme et al., 2008; Brass et al., 2009).”
Tetherin inhibits HIV-1 release by directly tethering virions to cells (2009, positive): “This is likely the reason why several viruses have independently evolved trans-acting tetherin antagonists such as HIV-1 Vpu (Neil et al., 2008; Van Damme et al., 2008), SIV Nef (Jia et al., 2009; Zhang et al., 2009), Ebola GP (Kaletsky et al., 2009), KSHV K5 (Bartee et al., 2006), and, possibly,…”