Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer.
By Dnyaneshwar Kalyane, Nidhi Raval, R. Maheshwari, V. Tambe, K. Kalia, R. Tekade. Materials Science and Engineering C: Materials for Biological Applications, 2019
719 citations recorded by the source corpus.
In tumorous tissues, the absence of vasculature supportive tissues intimates the formation of leaky vessels and pores (100 nm to 2 μm in diameter) and the poor lymphatic system offers great opportunity to treat cancer and the phenomenon is known as Enhanced permeability and retention (EPR) effect. The trends in treating cancer by making use of EPR effect is increasing day by day and generate multitudes of possibility to design novel anticancer therapeutics. This review aimed to present various factors affecting the EPR effect along with important things to know about EPR effect such as tumor perfusion, lymphatic function, interstitial penetration, vascular permeability, nanoparticle retention etc. This manuscript expounds the current advances and cross-talks the developments made in the of EPR effect-based therapeutics in cancer therapy along with a transactional view of its current clinical and industrial aspects.
Subfields: Biomaterials, Biomedical Engineering
View Paper: https://www.semanticscholar.org/paper/3596ab4e8320b778af313613b8a8d3d2b79e592e
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In Biomaterials
In Biomedical Engineering
Citations in the corpus
- Nanomedicine in cancer therapy (2023, background): “23,48 61 – 64 In addition, tumor vasculature occlusion or embolization, which was triggered by bleeding or activated fi brinolysis, can damage the EPR effect by impairing blood fl ow.”
- A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives (2022, background): “capillaries (100 nm–2 μm depending upon the size and type of tumor tissue [22]).”