Depression and Type 2 Diabetes Over the Lifespan: A Meta-Analysis
By A. Nouwen, C. Lloyd, F. Pouwer. Diabetes Care, 2009
858 citations recorded by the source corpus.
We read with interest the meta-analysis by Mezuk et al. (1) on the bidirectional relationship between diabetes and depression. In their report, the authors examined whether having depression increases risk of type 2 diabetes and the inverse relationship, namely, whether having type 2 diabetes increases risk of depression. The authors concluded that depression was associated with a 60% increased risk of developing type 2 diabetes but that there was only a modest (15%) increased risk of depression in individuals with type 2 diabetes. While we welcome this report, we would argue that there are a number of important methodological and conceptual issues that …
Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology
View Paper: https://www.semanticscholar.org/paper/3581dc8d0c4e141f9bbbd8a84b1cb8bc46cdc2a7
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In Endocrinology, Diabetes and Metabolism
In Epidemiology
Citations in the corpus
- Insulin resistance: Genetic associations with depression and cognition in population based cohorts (2019, positive): “Meta-analyses indicate that depression increases the risk for the subsequent development of INS-R (Pan et al., 2012; Penninx, 2017) and T2D (Knol et al., 2006; Mezuk et al., 2008).”
- Is depression associated with increased oxidative stress? A systematic review and meta-analysis. (2015, neutral): “…that are usually associated with increasing age such as cardiovascular disease (Nicholson et al., 2006), obesity (Luppino et al., 2010), diabetes (Mezuk et al., 2008), cancer (Chida et al., 2008), cognitive impairment (Barnes et al., 2006) and have a higher all-cause mortality rate (Cuijpers et…”
- Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile (2013, background): “However, the increased somatic morbidity has also been found in patients fulfilling psychiatric diagnostic criteria, who - in line with a dose–response association have slightly higher incident morbidity rates [3-5].”
- Diabetes Distress but Not Clinical Depression or Depressive Symptoms Is Associated With Glycemic Control in Both Cross-Sectional and Longitudinal Analyses (2009, background): “There are substantive data to suggest that depression is indeed a risk factor for subsequent diabetes (4) and that there may be a bidirectional relationship between depression and diabetes over time (5).”
- HPA Axis in Major Depression: Cortisol, Clinical Symptomatology, and Genetic Variation Predict Cognition (2016, background): “Depression may precede Type II diabetes (T2D; (46)), independent of any effects of antidepressant medication (47).”