DNA methylation pathways and their crosstalk with histone methylation

By Jiamu Du, L. Johnson, Steven E. Jacobsen, Dinshaw J. Patel. Nature reviews. Molecular cell biology, 2015

854 citations recorded by the source corpus.

Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division. Protein structural domains that specifically recognize methylated DNA and methylated histones are key for targeting enzymes that catalyse these marks to appropriate genome sites. Genetic, genomic, structural and biochemical data reveal connections between these two epigenetic marks, and these domains mediate much of the crosstalk.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3500ee90b8e5bce8e4690c544e0e129bbf9893c8

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In Molecular Biology

1. J. Lämke
2. E. Raiber
3. Shankar Balasubramanian
4. I. Bäurle
5. P. V. Delft
6. Robyn E. Hardisty

Citations in the corpus

• Mapping and elucidating the function of modified bases in DNA (2017, background): “Indeed, it is becoming clear that epigenetic crosstalk exists between DNA marks and key chromatin components; this crosstalk involves various chromatin-remodeling proteins [G].(15)”
• Epigenetic and chromatin-based mechanisms in environmental stress adaptation and stress memory in plants (2017, background): “In plants, cytosines may be methylated in all sequence contexts (CG, CHG, or CHH) and, depending on the context, symmetrical and asymmetrical DNA methylation is distinguished [10, 11].”