Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro.

By I. Meerts, J. J. V. Zanden, E. Luijks, I. V. Leeuwen-Bol, G. Marsh, E. Jakobsson, Åke Bergman, A. Brouwer. Toxicological Sciences, 2000

917 citations recorded by the source corpus.

Subfields: Genetics, Health, Toxicology and Mutagenesis, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/34d57872a69516cce034aed92e2e57f056e032a1

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Citations in the corpus

• In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds. (2001, background): “Information on the endocrine activity of hydroxylated PBDEs is presently limited to the ability of several HO-PBDEs to bind competitively to the thyroid hormone receptor (25) and to TTR (13).”
• Toxic effects of brominated flame retardants in man and in wildlife. (2003, background): “TBBPA was shown to be an effective binder to human transthyretin (TTR) in vitro, with ca. 10 time higher potency than thyroxin, the natural ligand (Meerts et al., 2000).”
• Fireproof killer whales (Orcinus orca): flame-retardant chemicals and the conservation imperative in the charismatic icon of British Columbia, Canada (2006, background): “However, as with the PCBs, PBDE metabolites appear to be potent competitors for thyroxine in circulation, where they displace this hormone from its carrier complex (Meerts et al. 2000) or increase elimination via upregulation of phase II uridinediphosphate-glucuronosyltransferase (UDGPT) enzyme acti”
• An overview of commercially used brominated flame retardants, their applications, their use patterns in different countries/regions and possible modes of release. (2003, background): “The key concern with TBBPA is its similarity in chemical structure to thyroxine (T4); Meerts et al. (2000), in in vitro T4-TTR assay showed that TBBPA has stronger affinity for binding with the thyroid hormone transport protein transthyretin (TTR) than the natural ligand T4.”
• Brominated flame retardants: cause for concern? (2003, neutral): “One in vitro study showed that PBDEs, as parent compounds, do not compete with T4–TTR binding and that only hydroxy metabolites of the PBDEs tested displaced T4 from TTR (Meerts et al. 2000).”