Functional boundaries in the human cerebellum revealed by a multi-domain task battery

By Maedbh King, C. Hernandez-Castillo, Russell A. Poldrack, Richard B. Ivry, Jörn Diedrichsen. Nature Neuroscience, 2019

623 citations recorded by the source corpus.

There is compelling evidence that the human cerebellum is engaged in a wide array of motor and cognitive tasks. A fundamental question centers on whether the cerebellum is organized into distinct functional subregions. To address this question, we employed a rich task battery designed to tap into a broad range of cognitive processes. During four functional MRI sessions, participants performed a battery of 26 diverse tasks comprising 47 unique conditions. Using the data from this multi-domain task battery, we derived a comprehensive functional parcellation of the cerebellar cortex and evaluated it by predicting functional boundaries in a novel set of tasks. The new parcellation successfully identified distinct functional subregions, providing significant improvements over existing parcellations derived from task-free data. Lobular boundaries, commonly used to summarize functional data, did not coincide with functional subdivisions. The new parcellation provides a functional atlas to guide future neuroimaging studies. Using a large task battery spanning motor, cognitive, social and affective domains, this functional MRI (fMRI) study provides a comprehensive functional map of the human cerebellum, along with a comparison to maps derived from anatomy and resting-state fMRI data.

Subfields: Cognitive Neuroscience, Neurology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/34b11ffd4580b37ce87a91e00f20b94591222666

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Citations in the corpus

Hungry Hungry Hippos: Towards Language Modeling with State Space Models (2022, methodology): “…functional neuroimaging data by ﬁrst pre-training models on a broad fMRI dataset spanning 11 , 980 fMRI runs from 1 , 726 individuals across 34 datasets and subsequently adapting the pre-trained models to two downstream mental state decoding datasets (namely, the HCP [61] and MDTB [38] datasets).”
The OpenNeuro resource for sharing of neuroscience data (2021, positive): “…natural images; the Individual Brain Charting dataset ( Pinho et al., 2020 ; Pinho et al., 2018 ), which includes data from individuals each completing 24 different tasks, and the Multidomain Task Battery dataset ( King et al., 2019 ), which includes data from individuals each completing 26 tasks.”