Brain nicotinic acetylcholine receptors: native subtypes and their relevance.

By Cecilia Gotti, Michele Zoli, F. Clementi. TIPS - Trends in Pharmacological Sciences, 2006

918 citations recorded by the source corpus.

Neuronal nicotinic acetylcholine receptors comprise a heterogeneous class of cationic channels that is present throughout the nervous system. These channels are involved both in physiological functions (including cognition, reward, motor activity and analgesia) and in pathological conditions such as Alzheimer's disease, Parkinson's disease, some forms of epilepsy, depression, autism and schizophrenia. They are also the targets of tobacco-smoking effects and addiction. Neuronal nicotinic acetylcholine receptors are pentamers of homomeric or heteromeric combinations of alpha (alpha2-alpha10) and beta (beta2-beta4) subunits, which have different pharmacological and biophysical properties and locations in the brain. The lack of subtype-specific ligands and the fact that many neuronal cells express multiple subtypes initially hampered the identification of the different native nicotinic acetylcholine receptor subtypes, but the increasing knowledge of subtype composition and roles will be of considerable interest for the development of new and clinically useful nicotinic acetylcholine receptor ligands.

Subfields: Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/3490a3bac0f2d9f2c912df82f18f8994bc5b4d9e

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In Molecular Biology

In Pharmacology

N. Benowitz

Citations in the corpus

A Single-Cell Atlas of Cell Types, States, and Other Transcriptional Patterns from Nine Regions of the Adult Mouse Brain (2018, background): “The second – based traditionally on processing limbic versus sensory/motor information – groups SPNs into two spatial compartments within the striatum, the so-called “patch” and “matrix” compartments (Gerfen, 1992; Graybiel and Ragsdale, 1978).”
Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline (2016, neutral): “Both classes of AChRs are distributed widely throughout the brain (Gotti et al., 2006; Thiele, 2013).”
Variants in nicotinic receptors and risk for nicotine dependence. (2008, background): “The α3 subunit has limited distribution in the brain and forms α3β2 and α3β4 receptors (7).”
Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain (2018, background): “To assess whether gene-gene expression correlations captured known functional relationships, we focused first on subunits of nicotinic acetylcholine (ACh) receptors (nAChRs, n = 16 genes)—ligand-gated, pentameric ion channels whose eclectic but well-described subunit combinations are known to vary b”
Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics (2009, background): “The nAChR complex is composed of five subunits and is found in both the peripheral and central nervous systems (3).”
Ca2+ Permeability of the (α4)3(β2)2 Stoichiometry Greatly Exceeds That of (α4)2(β2)3 Human Acetylcholine Receptors (2006, background): “Neuronal AChRs are formed from a variety of pentameric combinations of subunits 2– 10 and 2– 4 (Lindstrom, 2000; Gotti et al., 2006; Sine and Engel, 2006).”