Comparison of 17,641 Patients With Right- and Left-Sided Colon Cancer: Differences in Epidemiology, Perioperative Course, Histology, and Survival

By F. Benedix, R. Kube, F. Meyer, U. Schmidt, I. Gastinger, H. Lippert. Diseases of the Colon & Rectum, 2010

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Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features. (2014, background): “[12-14] [15] We hypothesized that the carcinogenic pathway is different between proximal and distal colon tumors and that this would be reflected in size associated differences in the molecular characteristics of the tumors.”
Impact of BRAF Mutation and Microsatellite Instability on the Pattern of Metastatic Spread and Prognosis in Metastatic Colorectal Cancer (2011, background): “It has long been known that right-sided and left-sided tumors have different patterns of spread that have been attributed to tumor biology.(23) Given the strong association between rightsided tumors and BRAF mutations, the results of this study suggest that BRAF mutations may be the genetic alterati”