Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence

By Colin G. McNamara, Álvaro Tejero-Cantero, S. Trouche, Natalia Campo-Urriza, David Dupret. 2014

452 citations recorded by the source corpus.

We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neuroscience

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Citations in the corpus

Prioritized Experience Replay (2015, background): “Experiences with high magnitude TD error also appear to be replayed more often (Singer & Frank, 2009; McNamara et al., 2014).”
Selective Experience Replay for Lifelong Learning (2018, background): “Surprise Unexpected events have been shown to be connected to replay in rodents (McNamara et al. 2014; Cheng and Frank 2008) and surprise has a convenient counter-part in incremental reinforcement learning methods like Q-learning.”
A novel DDPG method with prioritized experience replay (2017, background): “During the learning process, instead of replaying all experiences uniformly, we tend to frequently replay experiences associated with more successful attempts and similar ideas can be referred to [9], [10].”
The content of hippocampal “replay” (2018, background): “The presence of spatially remote replay provides strong evidence that immediate sensory input is not the exclusive driver of replay content, even though external input can bias the content of replay (Bendor & Wilson, 2012; McNamara et al., 2014).”
The Role of Hippocampal Replay in Memory and Planning (2018, background): “Indeed, optogenetically triggering dopamine release in mice during exposure to a novel environment results in stronger CA1 reactivations of that environment during rest and a concomitant increase inmemory retention [147].”
What Learning Systems do Intelligent Agents Need? Complementary Learning Systems Theory Updated. (2016, unknown): “…suggests speci ﬁ c molecular mechanisms that support the stabilization of memories and speci ﬁ c neuromodulatory projections to the hippocampus [83,86 – 88] that allow the persistence of individual experiences in the hippocampus to be modulated by events that occur both before and afterwards,…”
Reverse replay of hippocampal place cells is uniquely modulated by changing reward (2016, unknown): “, 2015) and that activation of dopamine neurons during experience can promote later hippocampal reactivation during rest and memory consolidation (McNamara et al., 2014).”
Awake reactivation of emotional memory traces through hippocampal-neocortical interactions (2016, unknown): “enhances reactivation of pyramidal cell assemblies during subsequent sleep/rest (McNamara et al., 2014).”
Hippocampal Offline Reactivation Consolidates Recently Formed Cell Assembly Patterns during Sharp Wave-Ripples (2016, background): “Consistent with a role for reactivation in memory consolidation, co-firing patterns associated with spatial novelty or rewarded learning are reactivated more strongly (O’Neill et al., 2008; Singer and Frank, 2009; McNamara et al., 2014), and electrical disruption of hippocampal SWRs during sleep imp”
Post-learning hippocampal dynamics promote preferential retention of rewarding events (2016, background): “These findings closely parallel results showing that preferential reactivation of place cell sequences associated with rewards is related to preferential memory for reactivated contexts (Lansink et al., 2009; McNamara et al., 2014; Singer and Frank, 2009).”
Replay Comes of Age. (2017, unknown): “Recent results have shown that stimulation of dopamine neurons can promote hippocampal reactivation, although it is not known whether replay, and in particular reverse replay, is involved (McNamara et al. 2014).”