Function-oriented synthesis, step economy, and drug design.

By P. Wender, Vishal A. Verma, Thomas J Paxton, Thomas H. Pillow. Accounts of Chemical Research, 2008

955 citations recorded by the source corpus.

Subfields: Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/3412315a70482b97639717c7b1ffc9a48ddd4ac9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Gisbert Schneider
2. Roderick E. Hubbard
3. Markus Hartenfeller

In Organic Chemistry

1. Gisbert Schneider

Citations in the corpus

• Automating drug discovery (2017, background): “3e highlights the concept of automated morphing of natural products into synthetically accessible, isofunctional compounds, and illustrates the FOS design concept introduced previously.”
• Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery (2018, background): “An even advanced concept is the function-oriented synthesis which seeks to mimic the function of a promising compound in order to get simple scaffolds and make their synthesis easier and simple [213,229,230].”