Protein Structure and Function Prediction Using I-TASSER
By Jianyi Yang, Yang Zhang. Current Protocols in Bioinformatics, 2015
496 citations recorded by the source corpus.
I‐TASSER is a hierarchical protocol for automated protein structure prediction and structure‐based function annotation. Starting from the amino acid sequence of target proteins, I‐TASSER first generates full‐length atomic structural models from multiple threading alignments and iterative structural assembly simulations followed by atomic‐level structure refinement. The biological functions of the protein, including ligand‐binding sites, enzyme commission number, and gene ontology terms, are then inferred from known protein function databases based on sequence and structure profile comparisons. I‐TASSER is freely available as both an on‐line server and a stand‐alone package. This unit describes how to use the I‐TASSER protocol to generate structure and function prediction and how to interpret the prediction results, as well as alternative approaches for further improving the I‐TASSER modeling quality for distant‐homologous and multi‐domain protein targets. © 2015 by John Wiley & Sons, Inc.
Subfields: Materials Chemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/33b9dd3a55e161f5bfd42ab1312a9526af1de080
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Citations in the corpus
- Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses (2021, methodology): “CLMS analysis In order to sample the accessible interaction volume of the SAMHD1-CtD consistent with CLMS data, a model for SAMHD1 was generated using I-TASSER [112].”