The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity

By L. Macomber, J. Imlay. Proceedings of the National Academy of Sciences of the United States of America, 2009

1,079 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Hematology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/339b958f9ccb9b9a970586b2d45f2a560d3c733f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

1. G. Grass
2. C. Rensing

In Nutrition and Dietetics

1. G. Grass
2. C. Rensing

Citations in the corpus

• Metallic Copper as an Antimicrobial Surface (2010, background): “An alternative route of copper ion toxicity has been shown to be the displacement of iron from iron-sulfur clusters (20).”
• Antibacterial approaches in tissue engineering using metal ions and nanoparticles: From mechanisms to applications (2021, background): “Another prominent example is the enzyme isopropylmalate dehydratase, which is involved in the biosynthesis of branched-chain amino acids, which is readily inhibited by copper [141].”