Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.

By Yoon-Jae Cho, Aviad Tsherniak, Pablo Tamayo, S. Santagata, A. Ligon, H. Greulich, Rameen Berhoukim, V. Amani, L. Goumnerova, C. Eberhart and 10 more. Journal of Clinical Oncology, 2011

677 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics

View Paper: https://www.semanticscholar.org/paper/335b30c82955a89f6178a4d9ebf8e730fa8d6b2c

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In Cancer Research

1. Gad Getz
2. Jill P. Mesirov
3. Matthew Meyerson
4. Kristian Cibulskis
5. M. Lawrence
6. C. Russ

In Genetics

1. Gad Getz
2. Richard J. Gilbertson
3. Stacey Gabriel
4. Daniel C. Koboldt

Citations in the corpus

• MEDULLOBLASTOMA EXOME SEQUENCING UNCOVERS SUBTYPE-SPECIFIC SOMATIC MUTATIONS (2012, methodology): “Recent efforts profiling transcriptional and DNA copy number changes in medulloblastoma have provided insights into the biological processes involved in these tumours and have under-scored the molecular heterogeneity of this disease 2–4 .”
• The whole-genome landscape of medulloblastoma subtypes (2017, neutral): “Notable similarities between Group 3 and Group 4 have been discussed, including ambiguous cases that exhibit features characteristic of either subgroup 33–35 .”
• Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations (2012, positive): “We chose this threshold as we and others have demonstrated that whereas sporadic medulloblastomas display a high degree of variability in the level of observed copy number alterations, specific patterns of alternating copy-number patterns with multiple breakpoints localized on one chromosome, involv”
• The Molecular Signatures Database (MSigDB) hallmark gene set collection (2015, neutral): “In 2011, Cho et al. (2011) analyzed transcriptomes of a collection of 189 primary medulloblastoma tumors.”
• Subgroup-specific structural variation across 1,000 medulloblastoma genomes (2012, neutral): “23[83] 8p12[3] 9p23[3] CDKN2A/B [18] PTCH1 [5] KLF4 [10]”
• Molecular subgroups of medulloblastoma: the current consensus (2011, background): “Some recent series [28], but not others [7] have found a preponderance of females among Shh medulloblastoma.”