Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer.

By J. Kukowska-Latallo, Kimberly A. Candido, Zhengyi Cao, Shraddha S. Nigavekar, I. Majoros, Thommey P. Thomas, L. Balogh, Mohamed K Khan, J. Baker. Cancer Research, 2005

892 citations recorded by the source corpus.

Subfields: Biomaterials, Molecular Biology, Polymers and Plastics

View Paper: https://www.semanticscholar.org/paper/334e913aecb631e46439cb5421cc703a0337df66

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Citations in the corpus

Designing dendrimers for biological applications (2005, background): “PAMAM dendrimers have also been used as antitumor targeted carriers of methotrexat”
Nanomaterials and nanoparticles: Sources and toxicity (2007, background): “Nanoparticles are internalized not only by professional phagocytes such as alveolar macrophages [30], [145], [228], but by various types of cells, including endothelial cells [230], pulmonary epithelium [142], [231-236], gastrointestinal epithelium [204], red blood cells [203], [237], platelets [238”
Nanoparticles in Medicine: Therapeutic Applications and Developments (2008, background): “Moreover, the targeted, methotrexate-loaded dendrimer had less systemic toxicity than free methotrexate.(35) The promising properties of polyamidoamine dendrimers as a drug delivery system have led to further studies based on tunable architectures and molecular weights to optimize accumulation in tu”
Nanocarriers as an emerging platform for cancer therapy. (2007, background): “Direct coupling of these targeting agents to nanocarriers containing chemotherapies such as drugs has improved intracellular delivery and therapeutic outcome in animal tumour model”
Nanomedicine for drug delivery and imaging: A promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles (2007, background): “have synthesized folate-conjugated dendrimer nanoparticles coupled to methotrexate.(44) These nanoparticles accumulate in human KB tumors and livers tissue over 4 days after their administration because the liver and KB tumor cells express high levels of the folate receptor.”
Nanoparticles for Cancer Therapy: Current Progress and Challenges (2021, background): “mAb Nanoparticles Monoclonal antibodies are widely used in cancer treatment for their particular targeting abilities [65].”