The Varied Roles of Notch in Cancer

By J. Aster, W. Pear, S. Blacklow. Annual Review of Pathology, 2016

623 citations recorded by the source corpus.

Notch receptors influence cellular behavior by participating in a seemingly simple signaling pathway, but outcomes produced by Notch signaling are remarkably varied depending on signal dose and cell context. Here, after briefly reviewing new insights into physiologic mechanisms of Notch signaling in healthy tissues and defects in Notch signaling that contribute to congenital disorders and viral infection, we discuss the varied roles of Notch in cancer, focusing on cell autonomous activities that may be either oncogenic or tumor suppressive.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/32e3a6ee9d4c586f820213295a18cb139d956085

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Citations in the corpus

• Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge (2019, background): “Altered Notch signaling has diverse effects in human tumors and is implicated in all of the hallmarks of cancer, from immune system evasion to maintenance of CSCs [59].”