Role of Importin-β in Coupling Ran to Downstream Targets in Microtubule Assembly

By C. Wiese, A. Wilde, M. Moore, S. Adam, A. Merdes, Yixian Zheng. Science, 2001

310 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Transport into and out of the Nucleus (2001, background): “Finally, exciting links are being identified between Ran and other fundamental aspects of eukaryotic cell biology, including the control of spindle formation during mitosis and the formation of nuclear envelopes around chromatin during telophase (33, 111, 272, 273, 286, 287).”
Analysis of the Small GTPase Gene Superfamily of Arabidopsis1 (2003, background): “Association of RCC1 with chromatin results in localized generation of Ran:GTP in the vicinity of chromosomes, which in turn promotes microtubule spindle assembly (Carazo-Salas et al., 1999; Ohba et al., 1999; Wiese et al., 2001).”
Identification of genes periodically expressed in the human cell cycle and their expression in tumors. (2002, background): “Finally, it may be worth noting that Importin alpha, also in this cluster, has recently been shown to inhibit spindle assembly by binding a protein that promotes spindle formation, Repp86 (Xenopus TPX2) (Gruss et al., 2001; Nachury et al., 2001; Wiese et al., 2001).”