Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins

By Luqian Zheng, Jingjing Liu, Li-Na Niu, Mohammad Kamran, A. Yang, A. Jolma, Q. Dai, Timothy R. Hughes, Dinshaw J. Patel, Longjiang Zhang and 4 more. 2022

19 citations recorded by the source corpus.

In this study, Zheng et al. investigated how BEN factors, a recently recognized DNA binding module, identify their targets in humans. They characterize several mammalian BEN domain (BD) factors, including from two NACC family BTB-BEN proteins and from BEND3, which has four BDs, and provide structural insights into sequence-specific DNA binding by mammalian BEN proteins.

Subfields: Molecular Biology