Engineering exosomes as refined biological nanoplatforms for drug delivery

By Xin Luan, K. Sansanaphongpricha, I. Myers, Hongwei Chen, Hebao Yuan, Duxin Sun. Acta Pharmacologica Sinica, 2017

1,036 citations recorded by the source corpus.

Exosomes, a subgroup of extracellular vesicles (EVs), have been recognized as important mediators of long distance intercellular communication and are involved in a diverse range of biological processes. Because of their ideal native structure and characteristics, exosomes are promising nanocarriers for clinical use. Exosomes are engineered at the cellular level under natural conditions, but successful exosome modification requires further exploration. The focus of this paper is to summarize passive and active loading approaches, as well as specific exosome modifications and examples of the delivery of therapeutic and imaging molecules. Examples of exosomes derived from a variety of biological origins are also provided. The biocompatible characteristics of exosomes, with suitable modifications, can increase the stability and efficacy of imaging probes and therapeutics while enhancing cellular uptake. Challenges in clinical translation of exosome-based platforms from different cell sources and the advantages of each are also reviewed and discussed.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/32a9fb2ec387dfd3d4ca662430a69d5b8f887793

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In Cancer Research

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2. Chibuike C. Udenigwe
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Citations in the corpus

• Brief update on endocytosis of nanomedicines (2019, background): “Exosomes, produced inside the multivesicular bodies/late endosomal compartment, are being extracted and loaded with small molecules, proteins, and nucleic acids to deliver therapeutics to locations where synthetic vectors have achieved marginal success [5,36,38,39].”
• Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications (2020, neutral): “132,134 In summary, the above methods do not allow the combination of therapeutic agents with different properties to be loaded simultaneously, whether the pre-secretory loading or the post-secretory loading.”
• Plant exosome like nanovesicles: Emerging therapeutics and drug delivery nanoplatforms. (2020, methodology): “The characteristic intraluminal vesicles (ILVs), which actively and selectively incorporate RNAs, including mRNAs, microRNAs (miRNAs), and other non-coding RNAs along with lipids and DNA, dwell inside MVBs, which are ultimately integrated with plasmalemma to release PELNVs.23 PELNVs, being an integr”
• Naturally Occurring Exosome Vesicles as Potential Delivery Vehicle for Bioactive Compounds (2019, methodology): “Thus, exosomes can be efficient in long distance biological communication (Luan et al., 2017), as they would not be destroyed by the digestive condition and would likely remain unchanged until they reach their destination.”