Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study.

By E. Bateman, H. Boushey, J. Bousquet, W. Busse, T. Clark, R. Pauwels, S. Pedersen. American Journal of Respiratory and Critical Care Medicine, 2004

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An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. (2009, methodology): “Patients are usually required to achieve control in each outcome and/or for all the days of the week, for most or all the weeks of the assessment period (52, 227).”
Dupilumab in persistent asthma with elevated eosinophil levels. (2013, background): “Systemic glucocorticoid treatment 1 (2) 5 (10)”
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma (2013, background): “composite control scores (such as the Asthma Control Questionnaire or Asthma Control Test ACQ-7/ACT) remain at an uncontrolled level [210, 221, 222].”
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. (2010, positive): “Furthermore, this classification approach assumes that patients with asthma who are classified as intermittent, mild, moderate, and severe respond similarly to specific therapies, although optimal management strategies may not always be achieved, specifically in the patients with more severe or ‘‘di”