Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes.

By Hung-Jen Yen, S. Hsu, Ching‐Lin Tsai. Small, 2009

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Gold Nanoparticles for Photothermal Cancer Therapy (2019, background): “In contrast, the enhanced inflammatory response exhibited in another study can be explained by the fact that the sizes were larger on average, with sizes ranging from 14 to 100 nm, with larger sizes demonstrating the greatest upregulations in IL-1, IL-6, and TNF-alpha (Yen et al., 2009).”
Mechanisms of Silver Nanoparticle Release, Transformation and Toxicity: A Critical Review of Current Knowledge and Recommendations for Future Studies and Applications (2013, background): “In other studies, smaller particle size was not necessarily correlated with more dissolved silver [76,78], suggesting that coatings and interactions with biomolecules can influence dissolution rate, and need to be reported in detail to facilitate interpretation of the data, and indeed factored into ”
Engineered nanoparticles interacting with cells: size matters (2014, background): “AuNPs, increased toxicity for larger NPs; AgNPs, no size-dependence in toxicity [93]”