The role of cerium redox state in the SOD mimetic activity of nanoceria.
By Eric G Heckert, A. Karakoti, S. Seal, W. Self. Biomaterials, 2008
972 citations recorded by the source corpus.
Cerium oxide nanoparticles (nanoceria) have recently been shown to protect cells against oxidative stress in both cell culture and animal models. Nanoceria has been shown to exhibit superoxide dismutase (SOD) activity using a ferricytochrome C assay, and this mimetic activity that has been postulated to be responsible for cellular protection by nanoceria. The nature of nanoceria's antioxidant properties, specifically what physical characteristics make nanoceria effective at scavenging superoxide anion, is poorly understood. In this study electron paramagnetic resonance (EPR) analysis confirms the reactivity of nanoceria as an SOD mimetic. X-ray photoelectron spectroscopy (XPS) and UV-visible analyses of nanoceria treated with hydrogen peroxide demonstrate that a decrease in the Ce 3(+)/4(+) ratio correlates directly with a loss of SOD mimetic activity. These results strongly suggest that the surface oxidation state of nanoceria plays an integral role in the SOD mimetic activity of nanoceria and that ability of nanoceria to scavenge superoxide is directly related to cerium(III) concentrations at the surface of the particle.
Subfields: Electrical and Electronic Engineering, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/318db5c7da22d253af4324a3c6ed01bf663a879d
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Citations in the corpus
- Chemistry, Biochemistry of Nanoparticles, and Their Role in Antioxidant Defense System in Plants (2015, background): “5 mg/L probably due to the radical scavenging ability of nCeO2 (Heckert et al. 2008; Horie et al. 2011; Xia et al. 2008).”
- Surface modification of nanozymes (2017, background): “Nanoceria mimics the catalytic activity of a number of enzymes, including oxidase [24, 26], peroxidase [73, 74], catalase [75], SOD [70, 76], and phosphatase [25, 71, 77].”