Animal models of social stress: effects on behavior and brain neurochemical systems.

By R. J. Blanchard, C. McKittrick, D. Blanchard. Physiology and Behavior, 2001

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Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness (2016, background): “These stimuli have been previously validated as effective preclinical models of the social stressors associated with an increased risk of mental illness in humans (Blanchard et al. 2001).”
β-Adrenergic Receptor Antagonism Prevents Anxiety-like Behavior and Microglial Reactivity Induced by Repeated Social Defeat (2011, background): “These stressor-induced pathways have a profound influence on behavior, immunity, and physiology in both humans and rodents (Blanchard et al., 2001; Kiecolt-Glaser and Glaser, 2002; Kinsey et al., 2007; Cole et al., 2010).”
The Neuroendocrinology of Social Isolation (2014, background): “Once reintroduced into social settings, isolated male rodents often display a greater propensity for dominant/aggressive behavior (Blanchard et al. 2001), which has parallels in the increased negativity/hostility profile observed in lonely individuals but possibly less so in the socially…”