Targeting early infection to prevent HIV-1 mucosal transmission

By A. Haase. Nature, 2010

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How researchers see this paper

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Profound early control of highly pathogenic SIV by an effector-memory T cell vaccine (2011, positive): “…effector responses only after T CM have undergone antigen-stimulated expansion, differentiation and trafficking 6 -- too late to effectively control pathogens with the rapid replication and spread kinetics and highly developed immune evasion capabilities of the AIDS-causing lentiviruses 2,4,5 .”
Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation (2012, background): “HIV, which initially establishes foci of infection at the point of first contact (45), serves as a prominent example of this type of pathogen.”
HIV and Tuberculosis: a Deadly Human Syndemic (2011, background): “Since recent studies of the early stages of HIV infection have revealed that the local recruitment of CD4 T cells accelerates the early spread and progression of HIV (118, 119), it is also possible VOL.”
Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract (2015, background): “Activated CCR5+ CD4+ T cells at the cervical mucosal surface are likely the first susceptible cells to encounter HIV upon sex with an infected partner (Haase, 2010) and support greater HIV replication upon infection than resting cells (Meditz et al., 2011).”