High-speed Label-free Functional Photoacoustic Microscopy of Mouse Brain in Action

By Junjie Yao, Lidai Wang, Joon-Mo Yang, K. Maslov, T. T. Wong, Lei Li, Chih-Hsien Huang, J. Zou, Lihong V. Wang. Nature Methods, 2015

671 citations recorded by the source corpus.

We present fast functional photoacoustic microscopy (PAM) for three-dimensional high-resolution, high-speed imaging of the mouse brain, complementary to other imaging modalities. We implemented a single-wavelength pulse-width-based method with a one-dimensional imaging rate of 100 kHz to image blood oxygenation with capillary-level resolution. We applied PAM to image the vascular morphology, blood oxygenation, blood flow and oxygen metabolism in both resting and stimulated states in the mouse brain.

Subfields: Biomedical Engineering, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/30b77c1ee81c762e9a52705e1fe3386e8483b41c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Maizar Raissi
2. G. Em Karniadakis
3. Alireza Yazdani

In Radiology, Nuclear Medicine and Imaging

1. Maizar Raissi
2. G. Em Karniadakis

Citations in the corpus

• Hidden Fluid Mechanics: A Navier-Stokes Informed Deep Learning Framework for Assimilating Flow Visualization Data (2018, background): “Furthermore, recent advances in imaging such as the functional photoacoustic microscopy allows 3D blood oxygenation imaging with “capillary-level” resolution [44].”