Folic acid and folates: the feasibility for nutritional enhancement in plant foods

By J. Scott, F. Rébeillé, J. Fletcher. 2000

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Genetic diversity of folate profiles in seeds of common bean, lentil, chickpea and pea (2015, background): “Folates are water-soluble B vitamins and act as cofactors in many metabolic functions including the biosynthesis of nucleic acids, metabolism of amino acids, methylation of hormones, lipids, proteins, and DNA (Bailey and Gregory, 1999; Scott et al., 2000; Forges et al., 2007).”
Folate Synthesis and Metabolism in Plants and Prospects For Biofortification (2005, background): “…5-formylTHF content is to block its recycling by suppressing themato lines expressing vertebrate GTPCHIs (animals have GTPCHI for the production of another cofactor, activity of the enzyme (5-formyl-THF cycloligase) that reconverts it to 5,10-methenyl-THF (Scott et al., 2000).tetrahydrobiopterin).”