Role of genes and environments for explaining Alzheimer disease.

By M. Gatz, C. Reynolds, Laura Fratiglioni, B. Johansson, J. Mortimer, S. Berg, A. Fiske, N. Pedersen. Archives of General Psychiatry, 2006

1,739 citations recorded by the source corpus.

Subfields: Experimental and Cognitive Psychology, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/2fa4054eb5c08545c4edbb42a2f3e35854c9013b

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In Experimental and Cognitive Psychology

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Citations in the corpus

Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide (2007, background): “In a recent study of twins, heritability for AD was estimated to be between 58–79% ( Gatz et al, 2006 ).”
Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease (2011, neutral): “Alzheimer's disease is genetically complex and shows heritability of up to 79% (ref”
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020, background): “Genetic susceptibility is a prevalent factor in determining AD onset and pathogenesis, where heritability of various genetic factors are estimated to contribute to ~ 60–80% of all AD cases [440].”
The genetics of Alzheimer disease. (2012, background): “However, it is estimated that up to 80% of AD involves the inheritance of genetic factors, based on twin and family studies (Gatz et al. 2006).”
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes (2009, background): “Twin studies suggest that genes may have a role in more than 60% of Alzheimer's disease susceptibilit”
Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease (2014, background): “Rare monogenic forms of AD, the majority of which are attributable to mutations in one of three genes, APP, PSEN1 and PSEN2, exist, but common, lateonset AD is genetically complex with heritability estimated to be between 56–79%[1,2].”
Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease (2010, background): “Alzheimer’s disease (AD) is the leading cause of dementia [1,2] with a heritability of 56–79% [3].”
The Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception (2011, neutral): “Studies of twins have estimated the heritability of AD to be between approximately 60% and 80% [179], and until recently the only established genetic risk factor for AD was the APOE 34 allele, which accounts for approximately 50% of AD heritability [180].”
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses (2008, background): “Although the total number of AD risk genes and their precise identity remain elusive, there is good evidence suggesting that in combination they have a substantial impact on disease predisposition and age of onse”
The Role of Apolipoprotein E in Alzheimer’s Disease (2009, neutral): “Although nongenetic environmental factors, such as education and physical activity, may affect the risk of sporadic AD, twin studies strongly suggest that genetic factors play a critical role in lateonset AD (Gatz et al., 2006).”