High-Dose Atorvastatin after Stroke or Transient Ischemic Attack

By J. Provencio. 2007

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Reprint: 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults. (2014, background): “Specific statins and doses are noted in bold that were evaluated in RCTs (17,18,46-48,64-67,69-78) included in CQ1, CQ2 and the CTT 2010 meta-analysis included in CQ3 (20).”
2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. (2014, background): “Specific statins and doses are noted in bold that were evaluated in RCTs (17,18,46-48,64-67,69-78) included in CQ1, CQ2 and the CTT 2010 meta-analysis included in CQ3 (20).”
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias. (2016, background): “Secondary prevention therapy with statins reduces the risk of recurrent stroke (by 12%), MI and vascular death.(422,428) Statin pretreatment at TIA onset was associated with reduced recurrent early stroke risk in patients with carotid stenosis in a pooled data analysis, supporting an as-early-as-pos”
Factors Influencing the Decline in Stroke Mortality (2013, background): “The overall mortality rate was similar.(285) A post hoc analysis of the trial found that treatment with atorvastatin was independently associated with an increased risk of hemorrhagic stroke (HR, 1.”