Inhibiting the p53–MDM2 interaction: an important target for cancer therapy

By P. Chène. Nature Reviews. Cancer, 2003

723 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/2f6b5dcaba9678eacdd624df9035bfe34d47d5f8

How researchers see this paper

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In Molecular Biology

1. U. Moll
2. O. Petrenko

In Oncology

1. U. Moll
2. O. Petrenko

Citations in the corpus

• The MDM2-p53 interaction. (2003, background): “Sole microinjection of the 12/1 TIP protein plasmid, but not of an Ala substitution plasmid, induced massive p53 accumulation and a strong p53 reporter response in normal and MDM2overexpressing cell lines (40).”
• The proteasome: a suitable antineoplastic target (2004, neutral): “Depending on conditions, these responses might involve cell-cycle arrest, DNA repair, differentiation, senescence and apoptosis (for a review, see Ref”