Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice.

By Radoslaw Rola, J. Raber, Angela Rizk, S. Otsuka, S. Vandenberg, Duncan R. Morhardt, J. Fike. 2004

743 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Pulmonary and Respiratory Medicine

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In Developmental Neuroscience

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Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “) at different ages can result in substantially different behavioural phenotype”
Electroconvulsive seizure restores neurogenesis and hippocampus‐dependent fear memory after disruption by irradiation (2008, background): “Inflammation, characterized by an increase in activated microglia, is one factor involved in the suppression of neurogenesis by IRR (Ekdahl et al., 2003; Mizumatsu et al., 2003; Monje et al., 2003; Rola et al., 2004).”
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s. (2017, background): “Cognitive impairments are the most described functional defects observed in mice and humans following WBI [4,16].”
Mechanisms and functional implications of adult neurogenesis. (2008, neutral): “In contrast, X-ray irradiation of 3-week-old mice leads to opposite observations: impaired spatial learning and memory in the Morris water maze but not in the Barnes maze (Rola et al., 2004).”
Adult hippocampal neurogenesis, Rho kinase inhibition and enhancement of neuronal survival. (2013, background): “…with regards to neurogenesis and some hippocampal dependent tasks, it is noteworthy that novel object recognition, which was unaltered in our paradigm, is not affected by ablation (Madsen et al., 2003, Rola et al., 2004, Clelland et al., 2009) or enhancement of neurogenesis (Sahay et al., 2011).”
Radiation-induced brain injury: A review (2012, background): “A decrease in hippocampal neurogenesis has been correlated with deficits in hippocampal-dependent spatial learning and memory at 3 months after a single 5 Gy dose of WBI to 21-day-old mice (Rola et al., 2004).”
A putative role for neurogenesis in neuro-computational terms: inferences from a hippocampal model. (2009, neutral): “Furthermore, several authors have also reported that decreasing neurogenesis in young rats is correlated in time with a deficit in retention of hippocampus-dependent memories (Rola et al., 2004; Snyder, Hong, McDonald, & Wojtowicz, 2005).”
Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice (2007, neutral): “In comparison with previous studies (Monje et al., 2002; Santarelli et al., 2003; Rola et al., 2004), the rate at which we exposed the brain (i.e., 27 cGy/min) is 5– 10 times smaller.”
Structural Plasticity and Hippocampal Function (2010, neutral): “…et al. 2009; Dupret et al. 2008; Garthe et al. 2009; Hernandez-Rabaza et al. 2009; Jessberger et al. 2009; Imayoshi et al. 2008; Madsen et al. 2003; Raber et al. 2004; Rola et al. 2004; Saxe et al. 2006; Shors et al. 2001b, 2002; Snyder et al. 2005; Winocur et al. 2006; Zhang et al. 2008).”