Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis
By Bolin Wang, Ruo-bao Li, Zhong Lu, Y. Huang. Aging, 2020
1,193 citations recorded by the source corpus.
Currently, the number of patients with coronavirus disease 2019 (COVID-19) has increased rapidly, but relationship between comorbidity and patients with COVID-19 still not clear. The aim was to explore whether the presence of common comorbidities increases COVID-19 patients’ risk. A literature search was performed using the electronic platforms (PubMed, Cochrane Library, Embase, and other databases) to obtain relevant research studies published up to March 1, 2020. Relevant data of research endpoints in each study were extracted and merged. All data analysis was performed using Stata12.0 software. A total of 1558 patients with COVID-19 in 6 studies were enrolled in our meta-analysis eventually. Hypertension (OR: 2.29, P<0.001), diabetes (OR: 2.47, P<0.001), chronic obstructive pulmonary disease (COPD) (OR: 5.97, P<0.001), cardiovascular disease (OR: 2.93, P<0.001), and cerebrovascular disease (OR:3.89, P=0.002)were independent risk factors associated with COVID-19 patients. The meta-analysis revealed no correlation between increased risk of COVID-19 and liver disease, malignancy, or renal disease. Hypertension, diabetes, COPD, cardiovascular disease, and cerebrovascular disease are major risk factors for patients with COVID-19. Knowledge of these risk factors can be a resource for clinicians in the early appropriate medical management of patients with COVID-19.
Subfields: Infectious Diseases, Neurology, Oncology
View Paper: https://www.semanticscholar.org/paper/2ef54c7f3754fe274d577b5b23b5624c3fbbaac2
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Citations in the corpus
- Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis (2020, neutral): “Our results are similar to two small meta-analyses, by Fadini et al (6 studies, 1687 patients) and Wang et al (6 studies, 1558 patients), which gave odds ratio of 2.26 and 2.47, respectively, for diabetic patients developing more adverse disease due to SARS-CoV-2 infection [24, 28] .”
- Case Fatality Rate of Cancer Patients with COVID-19 in a New York Hospital System (2020, background): “5-fold increase for those with diabetes, possibly due to the underlying pulmonary and immune dysfunction (6, 7).”
- Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients (2021, background): “Another two small systematic reviews, by [67, 73] also suggested that diabetes is a determinant of severity and mortality of COVID-19 patients.”
- Levels and predictors of anxiety, depression and health anxiety during COVID-19 pandemic in Turkish society: The importance of gender (2020, methodology): “In addition, the elderly and individuals with chronic disease have an increased risk of contracting the disease (B. Wang et al., 2020).”