Analyzing Compositional Data with R

By K. G. van den Boogaart, Raimon Tolosana-Delgado. 2013

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Consistent and correctable bias in metagenomic sequencing experiments (2019, methodology): “In fact, our model of bias is equivalent to what is referred to as a compositional perturbation in the CoDA field; many CoDA methods are invariant to compositional perturbations (Aitchison, 2003; van den Boogaart and Tolosana-Delgado, 2013) and thus would be invariant to bias.”
Aitchison’s Compositional Data Analysis 40 Years on: A Reappraisal (2022, background): “ILRs have thus been called the “perfect black box” [83].”
Microbiome Datasets Are Compositional: And This Is Not Optional (2017, methodology): “The clr transformed values can be used as inputs for multivariate hypothesis testing using tools such as MANOVA, regression etc. (Van den Boogaart and Tolosana-Delgado, 2013) and for model building.”