Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

By J. Hirsh, K. Bauer, M. Donati, M. Gould, M. Samama, J. Weitz. Chest, 2008

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Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage (2016, methodology): “Subsequent administration is generally guided by the aPTT [234, 235].”
Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Fourth Edition) (2018, background): “Smaller-molecular-weight heparins will catalyze inhibition of only factor Xa.”
Dabigatran etexilate – a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity (2010, background): “In rapidly progressing haemostatic emergencies, such as pericardial, intraspinal or intracranial bleeds, the anticoagulant effects of heparins and vitamin K antagonists (VKA) can be reversed with protamine sulfate and prothrombin supplementation, respectively (28).”
Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition) (2009, background): “The risk of any (spontaneous, surgical, or anesthesia-related) bleeding due to heparin in such an anticoagulated patient may be increased, particularly if there is marked variation in the aPTT (regardless of themean aPTT).(26,62)Most importantly, the initiation of systemic therapeutic heparin therap”