Activity-based protein profiling: from enzyme chemistry to proteomic chemistry.

By B. Cravatt, A. Wright, J. Kozarich. Annual Review of Biochemistry, 2008

1,132 citations recorded by the source corpus.

How researchers see this paper

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The pharmacological landscape and therapeutic potential of serine hydrolases (2012, methodology): “This problem has been addressed by the development of a chemoproteomic technology termed activity-based protein profiling (ABPP”
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects (2008, neutral): “L-a-1-Palmitoyl-2-arachidonylphosphatidylcholine[arachidonyl-1-14C] (28) was purchased from PerkinElmer.”
Cysteine cathepsins: From structure, function and regulation to new frontiers (2011, background): “Their sophisticated chemistry makes it possible to characterize the enzyme function directly in native biological systems [128].”
Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator (2020, positive): “…that systemic treatment inhibits NOTUM activity in the V-SVZ, we used mass spectrometry-based activity-based protein profiling (MS-ABPP) (reviewed in Cravatt et al., 2008) and developed a targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to detect NOTUM-derived peptides.”
Target identification with quantitative activity based protein profiling (ABPP) (2017, background): “We refer readers to several other excellent reviews for a more in-depth and technical discussion of probe structure and function [16,29].”