Discovery and evaluation of inhibitors of human sphingosine kinase.

By K. French, Randy S. Schrecengost, Brian D. Lee, Zhuang Yan, Staci N Smith, Justin L Eberly, Jong K Yun, Charles D Smith. Cancer Research, 2003

643 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2e1537fbaac27e8f8def2f577768e721a920c427

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. S. Schiffmann
2. M. Kaufmann
3. K. Takabe
4. T. Karn
5. E. Ruckhäberle
6. U. Holtrich
7. A. Rody
8. G. Geisslinger

Citations in the corpus

• “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets (2008, background): “V) with nanomolar to low micromolar potencies, which were not competitive inhibitors at the ATP binding site of sphingosine kinase and also induced apoptosis of cancer cells (French et al., 2003, 2006).”
• Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer (2008, background): “The content of SPHK1 mRNA in tumor tissues (breast, brain, colon, lung) is higher than it is in healthy reference tissues [30].”