Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression.
By B. Bewernick, R. Hurlemann, A. Matusch, S. Kayser, C. Grubert, B. Hadrysiewicz, Nikolai Axmacher, M. Lemke, D. Cooper-Mahkorn, Michael X. Cohen and 4 more. Biological Psychiatry, 2010
805 citations recorded by the source corpus.
Subfields: Neurology, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/2dc6409c27426cad9ed1c60f15366a994a79e886
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Neurology
- Peter W. Kalivas
- Alvaro Pascual-Leone
- Steven C. Cramer
- Karl Deisseroth
- Leonardo G. Cohen
- Helen S. Mayberg
- Kent C. Berridge
- Sidney H. Kennedy
In Psychiatry and Mental health
- Patricia A. Reuter-Lorenz
- B. Kolb
- Morten L. Kringelbach
- Edith V. Sullivan
- A. Kramer
- Helen S. Mayberg
- John Q. Trojanowski
- Kent C. Berridge
Citations in the corpus
- Harnessing neuroplasticity for clinical applications (2011, positive): “Similar response rates have also been shown with stimulation of both the nucleus accumbens and anterior limb of the internal capsule (Malone et al., 2009; Bewernick et al., 2010), findings that also require further study.”
- An Evolutionary Framework to Understand Foraging, Wanting, and Desire: The Neuropsychology of the SEEKING System (2012, background): “, 2008) and longer-term antidepressant effects in extremely treatment-resistant patients suffering from major depression (Bewernick et al., 2010).”
- Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder. (2010, result): “These findings are consistent with observations by German investigators treating major depression with nucleus accumbens stimulation.(20) Another aspect that may have led to an underestimation of the effect of stimulation is that rating scales such as the Y-BOCS do not fully reflect improvement in p”
- Pleasure systems in the brain (2015, background): “Similarly, relief from anxiety or depression may be produced by some deep brain stimulations of the NAc or prefrontal cortex, resulting in positive engagement in social or leisure activities (Bewernick et al., 2010; Kennedy et al., 2011).”
- The Neurobiology of Anhedonia and Other Reward-Related Deficits (2011, methodology): “DBS of this region attenuated depression severity in half of the patients, with treatment responders showing a corresponding decrease in anhedonia [77].”
- Dopamine neurons modulate neural encoding and expression of depression-related behaviour (2012, background): “We examined the proportion of NAc neurons ( n 5 123) showing phasic responses to light pulses in VTA or phasic responses associated with FST kicks (Supplementary Figs 17 and 18).”
- Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder (2016, background): “The risk factors for suicidality with DBS are unclear but may be increased in those with a history of pre-DBS suicide or major concurrent psychosocial stressors.(92,93,99)”
- Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders (2015, background): “Small studies have suggested that DBS in several brain regions including the subgenual cingulate cortex and the nucleus accumbens may have antidepressant effects (Bewernick et al., 2010; Holtzheimer et al., 2012; Lozano et al., 2012; Merkl et al., 2013).”