Clinical relevance of age-related immune dysfunction.

By S. Castle. Clinical Infectious Diseases, 2000

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Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system (2005, background): “This is particularly important because aging is associated with immunosenescence (24) and the elderly are more susceptible to peripheral infections with increased mortality rates for individuals 65 yr of age and older (25).”