Targeting metastasis
By P. Steeg. Nature Reviews. Cancer, 2016
1,233 citations recorded by the source corpus.
Tumour metastasis, the movement of tumour cells from a primary site to progressively colonize distant organs, is a major contributor to the deaths of cancer patients. Therapeutic goals are the prevention of an initial metastasis in high-risk patients, shrinkage of established lesions and prevention of additional metastases in patients with limited disease. Instead of being autonomous, tumour cells engage in bidirectional interactions with metastatic microenvironments to alter antitumour immunity, the extracellular milieu, genomic stability, survival signalling, chemotherapeutic resistance and proliferative cycles. Can targeting of these interactions significantly improve patient outcomes? In this Review preclinical research, combination therapies and clinical trial designs are re-examined.
Subfields: Biotechnology, Oncology
View Paper: https://www.semanticscholar.org/paper/2d9eb83c5d0b228fb1e2b52575f30dc338c841db
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In Oncology
Citations in the corpus
- Integrative Clinical Genomics of Metastatic Cancer (2017, neutral): “Thus, it is preferable to match patients to potential therapies and clinical trials based on a real-time analysis of their metastatic tumor, rather than archival material of their primary tumor 2,10 .”
- EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, neutral): “TREATMENT AND RESISTANCE Metastatic cancer most often represents a terminal illness and patients eventually succumb to the disease or from complications that result from their course of treatment, indicating the current dearth of effective therapies (Steeg, 2016).”
- Unexpected high rate of early tumor recurrence in patients with HCV-related HCC undergoing interferon-free therapy. (2016, background): “The metastatic machinery is highly complex and involves tissue invasion, cell detachment from the stroma with anchor free survival while circulating in blood or lymph, nesting in a distant tissue/ organ, and ultimately, uncontrolled growth, intense angiogenesis to finally become detectable, first by”
- Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “The invasiveness of cancer cells into local tissue and seeding in areas distant from the original tumor to generate metastases are fundamental aspects of cancer malignancy [88], and metastasis remains the leading cause of mortality results from cancer [89].”