Mitotic misregulation and human aging.

By Danith H. Ly, D. Lockhart, R. Lerner, Peter G. Schultz. Science, 2000

602 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2d896dcc933ce33f7080f68e7ffb031560cbcdfa

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In Molecular Biology

Citations in the corpus

A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes (2001, background): “…creating terabytes of information, potentially capable of providing fundamental insights into biological processes ranging from gene function, to development, to cancer (Spellman et al. , 1998; Alon et al. , 1999; Golub et al. , 1999; Lee et al. , 1999; White et al. , 1999; Ly et al. , 2000).”
Forkhead Box M1 Regulates the Transcriptional Network of Genes Essential for Mitotic Progression and Genes Encoding the SCF (Skp2-Cks1) Ubiquitin Ligase (2005, methodology): “This published study used microarray analysis comparing gene expression profiles of proliferating fibroblasts from young versus old humans and allowed us to determined that the decrease in cellular proliferation in aging fibroblasts is associated with diminished expression of Foxm1 transcription fac”
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome (2005, background): “Several genes have been shown by microarray analysis to be differentially expressed in HGPS cell”
FoxM1 is required for execution of the mitotic programme and chromosome stability (2005, background): “Others have shown that FoxM1 is one of the most markedly downregulated genes in fibroblasts derived from normal, aged humans and from humans with Hutchinson–Gilford progeri”
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. (2001, unknown): “This concept was recently challenged by a study based on extensive gene array analysis suggesting errors in the mitotic machinery and possibly in arachidonic acid metabolism as being important determinants for the aging process [87].”
Genomics, gene expression and DNA arrays (2000, background): “Furthermore, confidence in the results is increased as conclusions are based on sets of genes that show a consistent response and that are consistently different between two or more sets of result”