The damage-response framework of microbial pathogenesis

By A. Casadevall, L. Pirofski. Nature Reviews Microbiology, 2003

630 citations recorded by the source corpus.

The late twentieth century witnessed the emergence of numerous infectious diseases that are caused by microorganisms that rarely cause disease in normal, healthy immunocompetent hosts. The emergence of these diseases shows that the existing concepts of pathogenicity and virulence do not take into account the fact that both the microorganism and the host contribute to microbial pathogenesis. To address this impediment to studies of host–microorganism interactions, we propose a new theoretical approach to understanding microbial pathogenesis, known as the 'damage-response' framework.

Subfields: Endocrinology, Food Science, Molecular Biology

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Citations in the corpus

• Foamy macrophages and the progression of the human TB granuloma (2009, background): “Although TNF is needed to drive granuloma development, too much of it can lead to overt tissue damag”
• Life history tradeoffs influence mortality associated with the amphibian pathogen Batrachochytrium dendrobatidis (2009, background): “Microbial pathogenesis is the outcome of a multifactorial context-dependent interaction between the host and its pathogen that results in costs to the host ( Casadevall and Pirofski 2003 ).”