Bleeding complications with warfarin use: a prevalent adverse effect resulting in regulatory action.

By D. Wysowski, P. Nourjah, Lynette Swartz. Archives of Internal Medicine, 2007

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Online Decision Making with High-Dimensional Covariates (2020, background): “Warfarin is a widely used oral anticoagulant agent; in 2004, more than 30 million prescriptions were written for this drug in the United States (Wysowski et al. 2007).”
A Regulatory Science Perspective on Warfarin Therapy: A Pharmacogenetic Opportunity (2009, background): “1% of all severe ADEs, second only to digoxin, in a 10-year survey.(5,9) The progressive increase in warfarin use and frequency of adverse events would seem to warrant better approaches to achieving the right dose as quickly and efficiently as possible in each individual patient.”