The Rb/E2F pathway and cancer.

By Joseph R. Nevins. Human Molecular Genetics, 2001

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Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells. (2003, background): “Pathways that modulate the activity of E2F are frequently disrupted in human cancers, leading to misregulated cellular proliferation (Nevins 2001).”
Role of interleukin-6 in cancer progression and therapeutic resistance (2016, background): “Mutations in the RB gene contribute to cellular transformation in various types of malignancies [93].”
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway (2010, background): “Importantly, mutations in the RB-E2F cascade are found in a wide range of tumor types [36,37].”
Myc and cell cycle control. (2015, background): “Transcription factors of the E2F family are critical for G1-S progression [7,116].”
The RB and p53 pathways in cancer. (2002, background): “RB, p130, and p107 physically interact with many proteins, but their binding to members of the E2F family of transcription factors appears to be central to their role in governing DNA replication (Dyson, 1998; Nevins, 2001; Trimarchi and Lees, 2002).”